Scientists have developed a 3D bioprinting platform that assembles functional មនុស្ស neural tissues. The progenitor cells in the printed tissues grow to form neural circuits and make functional connections with other neurons thus mimicking natural ខួរក្បាល tissues. This is a significant progress in neural tissue engineering and in 3D bioprinting technology. Such bioprinted neural tissues can be used in modelling មនុស្ស diseases (such as Alzheimer’s, Parkinson’s etc.) caused due to impairment of neural networks. Any investigation of disease of brain requires understanding how the មនុស្ស neural networks operate.
ជីវម៉ាស 3D គឺជាដំណើរការបន្ថែម ដែលសារធាតុជីវគីមីធម្មជាតិ ឬសំយោគសមស្រប (bioink) ត្រូវបានលាយឡំជាមួយកោសិការស់ និងបោះពុម្ពជាស្រទាប់ៗ ក្នុងរចនាសម្ព័ន្ធបីវិមាត្រដូចជាលិកាធម្មជាតិ។ កោសិកាលូតលាស់នៅក្នុង bioink ហើយរចនាសម្ព័ន្ធអភិវឌ្ឍដើម្បីធ្វើត្រាប់តាមជាលិកាឬសរីរាង្គធម្មជាតិ។ បច្ចេកវិទ្យានេះបានរកឃើញកម្មវិធីនៅក្នុង បង្កើតឡើងវិញ medicine for bioprinting of cells, tissues and organs and in research as model to study មនុស្ស រាងកាយ នៅក្នុង vitroជាពិសេស មនុស្ស ប្រព័ន្ធប្រសាទ។
ការសិក្សារបស់ មនុស្ស nervous system faces limitations due to unavailability of primary samples. Animal models are helpful but suffer from species-specific differences hence the imperative of នៅក្នុង vitro ម៉ូដែលនៃ មនុស្ស nervous system to investigate how the មនុស្ស neural networks operate towards finding treatments for diseases attributed to impairment of neural networks.
មនុសស neural tissues have been 3D printed in the past using stem cells however these lacked neural network formation. The printed tissue had not shown to have formed connections between cells for several reasons. These shortcomings have been overcome now.
នៅក្នុងការសិក្សាថ្មីៗនេះ អ្នកស្រាវជ្រាវ chose fibrin hydrogel (consisting of fibrinogen and thrombin) as the basic bioink and planned to print a layered structure in which progenitor cells could grow and form synapses within and across layers, but they changed the way layers are stacked during printing. Instead of traditional way of stacking layers vertically, they chose to print layers next to another horizontally. Apparently, this made the difference. Their 3D bioprinting platform was found to assemble functional មនុស្ស neural tissue. An improvement over other existing platforms, the មនុស្ស neural tissue printed by this platform formed neural networks and functional connections with other neurons and glial cells within and between layers. This is the first such case and is a significant step forward in neural tissue engineering. Laboratory synthesis of nerve tissue that mimics brain in function sounds exciting. This progress will certainly help researchers in modelling មនុស្ស diseases of brain caused due to impaired neural network to better understand the mechanism for finding a possible treatment.
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ឯកសារយោង:
- Cadena M. , et al 2020. ការបោះពុម្ព 3D នៃជាលិកាសរសៃប្រសាទ។ សម្ភារៈថែទាំសុខភាពកម្រិតខ្ពស់ ភាគ១០ លេខ ១៥ ២០០១៦០០។ DOI៖ https://doi.org/10.1002/adhm.202001600
- យ៉ាន អ៊ី., et al 2024. 3D bioprinting of មនុស្ស neural tissues with functional connectivity. Cell Stem Cell Technology| Volume 31, Issue 2, P260-274.E7, February 01, 2024. DOI: https://doi.org/10.1016/j.stem.2023.12.009
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